Toxic epidermal necrolysis is a severe form of Stevens-Johnson Syndrome. It’s a life threatening skin reaction that’s thought to be caused by an immune response to certain medications. The medications known to trigger TEN range from ibuprofen, certain antibiotics (penicillin being one), anticonvulsants, and steroids. We aren’t sure what exactly causes it or how to stop it. One day you’re taking something for your headache, a few days later you start getting painful red splotches on your skin. Once the first ones show up, they spread, often across your entire body. The redness grows and gets more painful, blisters form, and then your skin starts falling off! Everywhere! The only level of care at this point is to treat you like a severe burn patient, because that’s essentially what you are. With large swathes of skin completely gone from your body, the only recourse is skin grafts and management of symptoms. Infections are common during the healing process and the prognosis isn’t great. If it progresses into TEN, the odds of survival are about 50%. But don’t worry, it’s so rare and triggered by so many different medications it’s pointless to try to avoid it. If the good Lord decides to kill you with it, there’s nothing you can do about it!
I take lamotrigine for bipolar disorder. Had to watch for this every time I restart (gotta love that bipolar decision that you’re fine and stop taking your meds).
Shit, it does sounds like the condition of the daughter of a customer of mine. She basically just had antibiotics given from a doctor, and then the next day all these rashes appear and started to burn her skin off, and she had to be treated just like a burn patient. Last i heard she’s recovering, and the skin grow back so hopefully it get better. It’s really scary to listen to her retelling of the whole thing.
The small section in the wikipedia article you link to on HIV struck me (see here).
It says that HIV increases the chances of having TEN by 1000x, reasons also unknown. I don’t know if that makes sense given the pathology of HIV/AIDS, but it struck is another example of infection by pathogens having this long tail side effects that we may not know much about or be on top of (the Multiple Sclerosis and Glandular Fever thing recently being another notable one).
Toxic epidermal necrolysis is a severe form of Stevens-Johnson Syndrome. It’s a life threatening skin reaction that’s thought to be caused by an immune response to certain medications. The medications known to trigger TEN range from ibuprofen, certain antibiotics (penicillin being one), anticonvulsants, and steroids. We aren’t sure what exactly causes it or how to stop it. One day you’re taking something for your headache, a few days later you start getting painful red splotches on your skin. Once the first ones show up, they spread, often across your entire body. The redness grows and gets more painful, blisters form, and then your skin starts falling off! Everywhere! The only level of care at this point is to treat you like a severe burn patient, because that’s essentially what you are. With large swathes of skin completely gone from your body, the only recourse is skin grafts and management of symptoms. Infections are common during the healing process and the prognosis isn’t great. If it progresses into TEN, the odds of survival are about 50%. But don’t worry, it’s so rare and triggered by so many different medications it’s pointless to try to avoid it. If the good Lord decides to kill you with it, there’s nothing you can do about it!
I take lamotrigine for bipolar disorder. Had to watch for this every time I restart (gotta love that bipolar decision that you’re fine and stop taking your meds).
Shit, it does sounds like the condition of the daughter of a customer of mine. She basically just had antibiotics given from a doctor, and then the next day all these rashes appear and started to burn her skin off, and she had to be treated just like a burn patient. Last i heard she’s recovering, and the skin grow back so hopefully it get better. It’s really scary to listen to her retelling of the whole thing.
The small section in the wikipedia article you link to on HIV struck me (see here).
It says that HIV increases the chances of having TEN by 1000x, reasons also unknown. I don’t know if that makes sense given the pathology of HIV/AIDS, but it struck is another example of infection by pathogens having this long tail side effects that we may not know much about or be on top of (the Multiple Sclerosis and Glandular Fever thing recently being another notable one).